Our data indicated that preoperative systemic immune coagulation cascade (SICC) [including NLR, LMR, platelet and fibrinogen (Fbg)] and postoperative tumor markers (TMs) [CA19-9, carcinoembryonic antigen (CEA) and carbohydrate antigen 242 (CA242)] were pivotal in prediction of early recurrence and low survival of PDAC patients with radical resection. The gene discussed is CEACAM5; the disease is neoplasm.