More recently, a CD1d-specific Vγ9Vδ2-T cell engager based on single-domain antibodies has been explored in preclinical CLL models, showing its capability of determining cytokine production and degranulation by Vγ9Vδ2-T cells from both CLL patients and controls, and of inducing CD1d-dependent tumor lysis (69). The gene discussed is CD1D; the disease is neoplasm.