Kaplan-Meier survival analysis showed that the overall survival of colon cancer patients with low ALOXE3 expression was significantly higher than that of those with high ALOXE3 expression, (P < 0.05), meanwhile the 5-year recurrence-free survival of colon cancer patients with high NOS2 expression was significantly higher than that of those with low NOS2 expression, and the difference was significant (P < 0.05). Here, NOS2 is linked to colonic neoplasm.