They used multivariate survival analysis and comprehensive prognosis to show that ALOXE3 and ALOX12 were associated with colon cancer OS, the low expression of both is better for the prognosis of COAD, and ALOXE3 combined with ALOX12 may serve as a potential prognostic biomarker for COAD. Here, ALOX12 is linked to malignant colon neoplasm.