Cluster M1 was significantly enriched in immune-related pathways such as Th1 and Th2 cell differentiation and antigen processing and presentation (Figure 5D), and high expression antigen presents HLA-related genes and inflammation-related genes (C3, IL2RA, LY86, CX3CR1) (51–53), and macrophages can promote tumor cell growth and metastasis by crosstalk with tumor cells through CX3CR1 (51). This evidence concerns the gene CX3CR1 and neoplasm.