BAX and type 1 diabetes mellitus: In T1DM-induced rats, a significant decrease in the mRNA levels of Bcl2 with a concomitant increase in mRNA levels of Bax, Bax/Bcl2, and protein levels of cleaved caspase-3 was observed as compared to control rats, and it was reversed in the T1DM + MA-treated rats (Figures 6(a)–6(d)).