Within this view, hyperglycaemia can induce massive quantities of ROS in the retina by promoting glucose auto-oxidation, impairing mitochondria oxidative phosphorylation, and activating numerous ROS generator mechanisms such as NADPH oxidase, protein kinase c (PKC), hexosamine, and AGE/RAGEs pathways [13]. This evidence concerns the gene FMO5 and Hyperglycemia.