EPAS1 and neoplasm: Among the four ICI-resistance-associated pathways, MTB cluster C2 with unfavored prognosis demonstrated elevated score of hypoxia and Wnt/Beta-catenin signalings which were consistent with existing studies that HIF-2α played a key role in tumor hypoxia environment and Wnt/Beta-catenin signalings produced protumourigenic activities [64, 65].