Interestingly, Shen et al. found APC activated mitochondrial autophagy through both cerebral ischemia in vivo and in vitro, but mitophagy and neuroprotection were abolished in PARK2 knockout mice, and APC-induced neuroprotection is related to PARK2-dependent mitophagy in the mouse model of MCAO [115]. This evidence concerns the gene APC and brain ischemia.