In the MIRI model, salidroside could attenuated the proinflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin- (IL-) 1β, and IL-6 in serum by inhibiting TLR4/NF-κB signaling pathway, and that could ameliorate cell apoptosis and the heart failure assessed by histopathological examination and TUNEL assay [24]. Here, TNF is linked to heart failure.