For instance, Alsaleem et al. developed a two-gene signature (ACSM4 and SPDYC) indicative of poor prognosis of TNBC [12]; Joe et al. explored a prognostic gene set with a total of 43 genes from the transcriptomic dataset of breast cancer; and Deng et al. discovered six hub genes (CDK1, CCNA2, TOP2A, CCNB1, KIF11, and MELK) associated with worse overall survival of breast cancer patients [13]. This evidence concerns the gene SPDYC and breast cancer.