As shown in Figure 8B, the expression of mitochondrial fission proteins (i.e., MFF, Fis1, and Drp1) was significantly increased in both the cortex and hippocampus of AD rats compared to WT animals (Cortex-MFF: P = 0.0004; Hippocampus-MFF: P = 0.0007; Cortex-Fis1: P = 0.0002; Hippocampus-Fis1: P = 0.0002; Cortex-Drp1: P = 0.0005; Hippocampus-Drp1: P = 0.001). Here, FIS1 is linked to Alzheimer disease.