IL1B and Alzheimer disease: As shown in Figure S5, the levels of pro-inflammatory cytokines (i.e., NFκB, TNF-α, and IL-1β) were significantly increased in the cortex and hippocampus of AD rats (Cortex-NFκB: P = 0.00173; Hippocampus-NFκB: P < 0.001; Cortex-TNF-α: P = 0.0005; Hippocampus-TNF-α: P = 0.0179; Cortex-IL-1β: P < 0.001; Hippocampus-IL-1β: P < 0.001).