As shown in Figure 6A, double staining of CD206, an M2 phenotype marker, with Iba-1 showed that CD206+/Iba-1+ cells were significantly increased in the cortex and hippocampus of AD animals with PBM treatment (Cortex: P = 0.0012; Hippocampus: P = 0.00013). Here, AIF1 is linked to Alzheimer disease.