As shown in Figure 9B, representative confocal microscopy images showed a robust decrease of Hbα and Hbβ in both the cortex and hippocampus of AD animals compared to WT (Hbα in the cortex: P = 0.0079; Hbα in the hippocampus: P = 0.0002; Hbβ in the cortex: P = 0.0105; Hbβ in the hippocampus: P = 0.0.0086). Here, HBB is linked to Alzheimer disease.