As shown in Figure 3B, AD animals displayed decreased expression of synaptophysin (Cortex: P = 0.0007; Hippocampus: P = 0.00641), PSD95 (P = 0.002; Hippocampus: P = 0.0053), and spinophilin (Cortex: P < 0.001; Hippocampus: P = 0.0025) in both the cortex and hippocampus compared with WT animals. Here, DLG4 is linked to Alzheimer disease.