To further investigate the role of HDAC5 in a model mimicking the mutational burden in human PDAC, we generated a mouse PDAC model using genetically engineered KPC mouse (KrasG12D/+; LSLTrp53R172H/+; Pdx-1-Cre) derived tumor cells (Figure 6A; Figure S6A-B). Here, PDX1 is linked to neoplasm.