GPC3 and hepatocellular carcinoma: GBE significantly enhanced the histological characteristics of liver tissue, decreasing the levels of alpha-fetoprotein (AFP), glypican-3 (GPC-3), and carcinoembryonic antigen (CEA) in HCC rats via the increased gene expression of inhibitor of growth (ING)-3 and the decreased gene expression of the transcription factor forkhead box protein 1 (FOXP1) in the liver [72].