Proliferation, aging, inflammation, positive regulation of gene expression, positive regulation of transcription, DNA templating, etc., and the pathways related to the treatment of psoriasis by HLXLD mainly involved pathways in cancer (including multisystem and multiorgan cancers), TNF signaling pathway, HIF-1 signaling pathway, T cell receptor signaling pathway, etc. At present, more and more pieces of evidence supported the correlation between cancer and psoriasis. The gene discussed is HIF1A; the disease is cancer.