Notch1 acts as an endogenous myocardial protective factor through the RISK/SAFE/HIF-1 alpha signaling, which reduces myocardial intracellular reactive oxygen species (ROS), enhances the myocardiocytes vitality, and significantly reduces the myocardial ischemia reperfusion injury [42]. The gene discussed is NOTCH1; the disease is myocardial ischemia.