We noticed that the behaviors of MMP12 were distinctly enhanced on ESCC specimens comparing to nontumor specimens, including MMP1 (Figure 1(b)), MMP3 (Figure 1(c)), MMP7 (Figure 1(d)), MMP8 (Figure 1(e)), MMP9 (Figure 1(f)), MMP13 (Figure 1(g)), MMP10 (Figure 1(h)), MMP11 (Figure 1(i)), MMP12 (Figure 1(j)), MMP14 (Figure 1(k)), MMP17 (Figure 1(l)), and MMP20 (Figure 1(m)). Here, MMP8 is linked to esophageal squamous cell carcinoma.