We noticed that the behaviors of MMP12 were distinctly enhanced on ESCC specimens comparing to nontumor specimens, including MMP1 (Figure 1(b)), MMP3 (Figure 1(c)), MMP7 (Figure 1(d)), MMP8 (Figure 1(e)), MMP9 (Figure 1(f)), MMP13 (Figure 1(g)), MMP10 (Figure 1(h)), MMP11 (Figure 1(i)), MMP12 (Figure 1(j)), MMP14 (Figure 1(k)), MMP17 (Figure 1(l)), and MMP20 (Figure 1(m)). The gene discussed is MMP20; the disease is esophageal squamous cell carcinoma.