Some biological markers have been established such as lactate, C-reactive protein (CRP), procalcitonin (PCT), B-type natriuretic peptide (BNP), and soluble RAGE (sRAGE) in sepsis, while lack of sensitivity and specificity limit their clinical application (Oberhoffer et al., 1999; Phua et al., 2008; Hamasaki et al., 2014; Débora Maria da Gomes Cunha and Yoshio Hamasaki, 2019). The gene discussed is CRP; the disease is Sepsis.