Zuo et al. reported that forkhead box P3 (FOXP3) gene alterations (deletion, somatic mutations of functional significance, and downregulation) are common in breast cancer samples, and they found that these alterations correlated significantly with HER2 overexpression regardless of the status of HER2 amplification (Zuo et al., 2007). This evidence concerns the gene ERBB2 and breast cancer.