Bedin et al. (2019) reported 4 C-terminal CUBN variants are associated with proteinuria and slightly increased GFR, according to the NGS results from patients with suspected hereditary renal disease and chronic proteinuria. In our study, relying on the NGS technique, the TLR2 gene was detected associated with proteinuria after kidney transplantation. The in vitro experiment on podocytes further confirmed our finding. Here, TLR2 is linked to Proteinuria.