Previous in vitro and in vivo studies have shown that DNTTIP1 interacts with histone deacetylase 1 (HDAC1) to control the status of p53 acetylation (Sawai et al., 2018), thus regulating the expression of several p53 target genes that participate in cell cycle arrest (Narayanan et al., 2003; Zhang et al., 2004) and promote tumor cell migration and invasion in oral squamous cell carcinomas (OSCCs). This evidence concerns the gene DNTTIP1 and oral cavity squamous cell carcinoma.