COVID-19-induced AngII aggregation has been shown to promote acute lung injury (ALI) by activating cytokine-induced inflammation, activating the nicotinamide adenine dinucleotide hydrogen (NADH)/nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidation system and vasoconstriction (49, 51, 52). Here, AGT is linked to acute respiratory distress syndrome.