CASP3 and COVID-19: The internalization of SARS-CoV-2 by platelets, either in vitro or in COVID-19 patients, results in the colocalization of SARS-CoV-2 with phosphorylated mixed lineage kinase domain-like protein (phospho-MLKL), a mediator of necroptosis, and caspase-3 on nonpermeabilized platelets (44).