PIK3CD and rheumatoid arthritis: Its inhibition by SMI (MN58b) suppressed cell migration and resistance to apoptosis of cultured fibroblast-like synoviocytes (FLS) by modulating PI3K-AKT and MAPK-ERK signaling pathways and abrogated joint inflammation and damage in a murine model of RA, thereby validating its candidature as a therapeutic target for RA (111).