In addition, interrogation of epigenetic underpinnings in patient-derived cell types, facilitated by methylation QTL, epigenome-wide association studies (EWASs) and the more recent methylC-capture sequencing (MCC-Seq) methods may further enhance cell- and context-specific functional interpretation of genetic variants like differentially methylated CpG sites in MHC locus in monocytes (78); IL-6 promoter region in PBMCs (79); and PTPN11 enhancer in RA FLS (80). This evidence concerns the gene PTPN11 and rheumatoid arthritis.