SERPINA1 and hyperinsulinemic hypoglycemia, familial, 4: Additionally, although not proven in our study, some conditions can interfere with the components of serum globulin [e.g. hyperlipoproteinemia (increase alpha-1 globulin), metastatic malignancy (increase alpha-1 and alpha-2 globulin), alpha-1 antitrypsin deficiency (decrease alpha-1 globulin), hemoglobin-haptoglobin complexes secondary to hemolysis (increase alpha-2 globulin), and iron-deficiency anemia with high transferrin (increase beta globulin)] (21).