IFNG and tuberculosis: Interferon-γ release assays (IGRAs) are tests used for evaluating cell-mediated host immune response according to T cells that release IFN-γ or the concentration of IFN-γ after stimulation by some of the RD1−encoded antigens (eg, the 6 kDa early secretory antigenic target [ESAT-6] and culture filtrate protein 10 [CFP-10] or TB 7.7) (5), and IGRAs are usually used to diagnose TB or LTBI, and as tools to identify new and more prominent antigen biomarkers.