TP53 and cancer: We also conducted GSEA analysis and filtered out 35 cancer hallmark gene sets significantly enriched in pan-glioma with having a ClCF1 high expression phenotype with the criterion of a normalized enrichment score >1.5, and identified apoptosis, coagulation, glycolysis, hypoxia, epithelial_mesenchymal_transition, and p53_pathway gene sets (Supplementary Figures S5A–H).