Polyphenols act through multiple pathways to suppress allergic asthma including suppression of inflammatory cytokines (82, 83), reversal of airway bronchoconstriction and bronchial hyper-reactivity (82, 84), downregulation of NF-κB activity (85), attenuation of oxidative stress (86), and promotion of healthy gut microbiota (87). This evidence concerns the gene NFKB1 and allergic asthma.