A large number of reports have indicated that UBE2L3 is involved in the occurrence and development of tumors, immune diseases, and Parkinson’s disease, through mainly the following signaling pathways: The nuclear transcription factor-kappa B (NF-κB) signaling pathway, GSK3β/p65 signaling pathway, p53 signaling pathway, autophagy mediated by p62, and DSB repair pathway. Here, TP53 is linked to immune system disorder.