A study reported that UBE2L3 promotes the ubiquitination and degradation of p27kip1 in non-small-cell lung cancer (NSCLC), and further study suggested that high expression of UBE2L3 led to the down-regulation of p27KIP1 protein levels, which are relevant to a poor prognosis for NSCLC (177). Here, UBE2L3 is linked to non-small cell lung carcinoma.