Except for anti-SSA (Figure 1F), seropositive SLE patients for anti-Sm, anti-dsDNA or anti-SSB antibodies had increased RNASE2 levels (Figures 1G–I), implying a possible link between upregulated RNASE2 and autoantibody production. The gene discussed is RNASE2; the disease is systemic lupus erythematosus.