RNASE2 and systemic lupus erythematosus: Previously, we have tested the plasma levels of RNase2 and found there were no difference between SLE patients and healthy controls (data not shown), suggesting that RNase2 is less likely to act through secretion to distant target tissues in SLE pathogenesis, although it is one of the four major secretory proteins released upon activation of eosinophils under normal circumstances (30, 31).