Besides this, Fndn5/Irisin and Apoa1, which have been shown to promote muscle hypertrophy and the systematic improvement of lipid and glucose metabolism (40–42), were largely declined in the muscle of NAFLD and NASH mice, overall suggesting the possible contribution of myokines on the systematic and pathological performance during NAFLD and NASH. This evidence concerns the gene APOA1 and metabolic dysfunction-associated steatotic liver disease.