Besides this, Mstn and Gdf11, two key muscle atrophy markers (37–39), as well as Stc2, a secreted glycoprotein highly expressed in the skeletal muscle and heart as a potent growth inhibitor for reduced skeletal muscle mass in rodents and human, were increased in the NAFLD and NASH groups (56, 57), yet it would be more convincing to confirm these myokine changes via ELISA analysis. This evidence concerns the gene STC2 and metabolic dysfunction-associated steatohepatitis.