Notably, lipid metabolic process as well as AMPK signaling pathway, PPAR signaling pathway, and insulin signaling pathway were uniquely upregulated in NASH mice as shown by the GO and KEGG analysis (Figures 7B, D), suggesting enforced lipid deposition and enhanced lipid and glucose metabolic dysfunctions in the skeletal muscle of NASH than the NAFLD group, while lipoprotein metabolic process as well as tight junction, MAPK signaling pathway, and focal adhesion were uniquely downregulated in the muscle from the NASH group (Figures 7C, E). The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.