In a double-blind RCT in T2D patients, a single dose of the GLP-1 analogue albiglutide did not impair the α-cell response or GH secretion when blood glucose was clamped in the hypoglycemic range (<59.4 mg/dl) (47); these results are in agreement with another study that analyzed the effects of exenatide administration (48). The gene discussed is GH1; the disease is type 2 diabetes mellitus.