showed the absence of hypoglycemic episodes in the presence of higher concentrations of GLP-1 when administered continuously; in this study, the Authors showed that the counter-regulatory responses in terms of changes of GH circulating levels were unaffected by GLP-1 administration during 48 h of fasting, which lead to the exhaustion of liver glycogen stores, without apparent increased risk of hypoglycemia (52). This evidence concerns the gene GCG and Hypoglycemia.