Indeed, the sustained dysfunction of insulin/IGF-1 signaling within the central nervous system negatively impacts cell functionality and viability, thus triggering a pathogenetic cascade, as observed in Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) (66). This evidence concerns the gene IGF1 and Huntington disease.