INS and Hypoglycemia: However, two limitations were detected: (i) the IOB constraint is computed as β times the IOB evolution considering the open-loop treatment, where the β factor is empirically established, and (ii) the rules for adapting the constraint dependedonly on the sign of d, and thus, there is not prediction regarding the changes in the variations (as in the iZMPC-ISL where the first and second time derivatives are used), leading to cases in which aggressive insulin doses are allowed precisely in the moments in which the variations start to decrease, which can cause hypoglycemia.