If the constraint is too high to counteract variations inducing hypoglycemia, then the insulin doses are higher than the required, and if the constraint is lower than the required to compensate for variations inducing hyperglycemia (see the range between 15:00h and 25:00h) the controller is constrained and thus the insulin doses are not enough to low BG levels. The gene discussed is INS; the disease is Hypoglycemia.