Still in the hypothesis of an involvement of the CFTR gene in the functioning of the gonadotropic axis, the literature reported a more delayed puberty in CF patients: older studies (23) attributed this delay to the precarious nutritional and pulmonary condition, but with the progress of treatment and the improvement in the health status of the patients, another study (24) showed that this delay in puberty is independent of the respiratory and nutritional parameters. Here, CFTR is linked to cystic fibrosis.