Guelfi et al. (2013) also showed that a reduction in fat mass after resistance training (3 sets of 10 repetitions at 75% 1RM progressed to 4 sets of 8 repetitions at 85% 1RM by the end of the intervention) did not coincide with changes in acylated ghrelin, PYY, or Pancreatic polypeptide concentrations in men with overweight/obesity (Guelfi et al., 2013). Additionally, another study in individuals with obesity reported training-induced elevations in fasting and postprandial Pancreatic polypeptide concentrations in the absence of body fat loss (Kanaley et al., 2014). The gene discussed is PPY; the disease is Obesity.