Interestingly, Martins et al. indicated that a 12-week supervised aerobic training (5times per week, 75% HRmax) in individuals with obesity-induced a mean decrease in body weight of 3.5 kg (from 96.2 to 92.7 kg) but had no significant effect on fasting or postprandial cholecystokinin concentrations (Martins et al., 2013). The gene discussed is CCK; the disease is obesity due to melanocortin 4 receptor deficiency.