TNF and systemic inflammatory response syndrome: Receptor interacting protein kinase 1(RIPK1)–dependent endothelial necroptosis underlies the TNF-induced systemic inflammatory response syndrome in mice (Zelic et al., 2018) and the blocking of connexin 43 hemichannels, which promote Ca2+ influx, with TAT-Gap19 protected mice against TNF-induced vascular leakage and mortality (Delvaeye et al., 2019).