Presumable mechanism of apoptosis in tumor epithelial cells (Figure 3) involves the interaction of bLf with the ITLN receptor, and once internalized, bLf may be translocated to nucleus where acts as trans-activator of p53 promotor via NF-κB activation as described for human neutrophil Lf in HeLa cells (Oh et al., 2004). Here, NFKB1 is linked to neoplasm.