IL18 and neoplasm: Experimental assays in tumor-bearing mice showed that unlike the apo form, only fully iron-saturated bLf functioned as an adjuvant for anticancer chemotherapy drugs by increasing Th1 (TNF-α, IFN-γ, and IL-18) and Th2 (IL-4, -5, -6, and -10) responses and nitric oxide (NO) production in homogenates from the small intestine; moreover, the protective effect required bLf feeding for 2 weeks prior to chemotherapy (Kanwar et al., 2008).