NFKB1 and neoplasm: SHK is a phosphatase inhibitor that interferes with cellular signaling mediated by TNF-α and NF-κB (Kondapi, 2020), and JQ1 is a first-in-class potent and selective inhibitor of the Bromodomain-containing protein 4 (BRD4) signaling pathway; it is widely used for tumor biology studies (Shi et al., 2018).