Immune surveillance encompasses very complex events, including apoptosis of tumor cells, inflammation and the immune response; all these events are mediated by components with an anticancer role in CRC, including innate immune cells such as natural killer cells (NKs), M1-type macrophages, dendritic cells (DCs), mast cells and adaptive immune cells such as TCD8+ cytotoxic cells, TCD4+ helper cells (Th1 phenotype secreting interferon (IFN)-γ, IL-12, and other proteins), Treg cells and Th17 helper cells (Koudougou et al., 2013; Wallace et al., 2014; Jacobs et al., 2015; Abraha and Ketema, 2016). Here, IFNG is linked to neoplasm.