In vitro studies using human CRC cells (HT-29) confirmed that both bLf and LfcinBs increase the expression of caspase-8, p53, and p21, critical proteins involved in tumor suppression, providing valuable information on the potential clinical applications of bLf and LfcinB in CRC therapy (Jiang and Lonnerdal, 2017). This evidence concerns the gene CASP8 and neoplasm.