However, in T2DM patients, 2-weeks treatment with empagliflozin or dapagliflozin reduced 2-deoxy-2-[18F]-fluoro-D-glucose reabsorption by 10%, simultaneously confirming the low affinity for SGLT2 (Rasul et al., 2020). This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.