A cross−sectional study in T2 diabetes found that a lower TG was associated with a reduced CVD risk in the short term (Ren et al., 2018); Mortality and morbidity from CVD were reduced via primary and secondary prevention through lipid−lowering therapy targeting LDL−C (Collins et al., 2016, Serban et al., 2016); HDL has antidiabetic functions by increasing insulin sensitivity and β−cell function (Cochran et al., 2021). Here, INS is linked to diabetes mellitus.