The baicalin, carthamin yellow, dauricine, (−)-epicatechin, kaempferol, and paeonol ameliorate neuronal ferroptosis in vitro or in vivo stroke models via regulating ACSL4, GPX4, TFR1, Fe2+, and NRF2 pathways (Chang et al., 2014; Duan et al., 2021; Guo et al., 2021; Jin Z. L. et al., 2021; Peng et al., 2021; Yuan et al., 2021), which show great potential in the treatment of stroke. Here, ACSL4 is linked to Stroke.