TP53 and brain ischemia: Ferritin reduces robust ROS production and GSH consumption; its decrease is necessary for cerebral ischemia-induced hippocampal neuronal ferroptosis through p53 and SLC7A11 in middle cerebral artery occlusion (MCAO) rats (Chen W. et al., 2021), and mice lacking mitochondrial ferritin show graver brain injury and neurological deficits, accompanied by typical ferroptotic event after cerebral ischemia/reperfusion (I/R) (Wang et al., 2021).