Ferroptosis, an autophagic cell death process, leads to autophagy activation and consequent ferritin and NCOA4 degradation (Gao et al., 2016), and NCOA4-regulated ferritinophagy maintains ferroptosis via mediating cellular iron homeostasis, which is also present in stroke (Li C. et al., 2021). The gene discussed is NCOA4; the disease is Stroke.