Albumin is a multifunctional protein in the ischemic brain that could play a neuroprotective role, such as inhibiting oxidative stress (Ishizaka et al., 2007), suppressing the various cytokines adhesion within post-capillary microcirculation (Belayev et al., 2002), modifying the platelet aggregation (George and Alastair, 1992; Maalej et al., 1999), and transporting the free fatty acids post-ischemia (Rodriguez de Turco et al., 2002). The gene discussed is ALB; the disease is ischemia.