Notably, higher plasma concentrations of the full-length receptor were reported in streptozotocin-induced diabetic mice, an effect which disappeared in mice treated with fiderastat, a molecule used to treat diabetic neuropathy, suggesting that the increase in full length p75NTR levels reflected diabetic neuropathic complications rather than diabetes itself (Chilton et al., 2004). Here, NGFR is linked to diabetic neuropathy.