AD is characterized by a cascade of pathological events, including the formation of amyloid plaques (made up of aggregated forms of Aβ), neurofibrillary tangles (composed of aggregated, hyperphosphorylated tau), synapse loss, brain hypometabolism, neuroimflammation, and brain atrophy that is accompanied by severe and progressive cognitive decline. This evidence concerns the gene MAPT and Mental deterioration.