Interestingly, such downregulation occurs despite normal serum iron (131.4 ± 23.4 mg/dL) and normal [179.5 (14–232.9 ng/mL)] or high [414.4 (328.2–1121 ng/mL)] ferritin levels in some HCC patients, as reported in one study [17] or elevated levels of iron, ferritin and transferrin saturation in the sera of HCC patients compared to control patients, as reported in another study [6]. The gene discussed is TF; the disease is hepatocellular carcinoma.