BMP6 is the most potent and predominant hepcidin inducer in response to excess iron but other BMPs like BMP9, BMP4 and BMP2 (BMP2 seems to stimulate basal hepcidin induction) can induce hepcidin transcription in HCC cell lines, primary human hepatocytes and mice models [29]. Here, BMP4 is linked to hepatocellular carcinoma.