C4B and cancer: The most common mutations derived from CH involve genes implicated in haematological tumorigenesis, such as DNMT3A, TET2, ASXL1 and JAK2, but also genes frequently mutated in solid tumours such as TP53, KRAS, PIK3CA and EGFR can be often reported, potentially leading to misinterpretation of the actionability of cancer [81, 124].