Consistently, the immunofluorescence analysis of γh2ax (Fig. S6D) and the TUNEL assay (Fig. S6E) showed that, only in the sh-Neg group, there was less DSBs and apoptosis in the tumor coinjected with CAFR1, which was attenuated by the anti-IL8 neutralizing antibodies. This evidence concerns the gene CXCL8 and neoplasm.