Finally, we observed that the knockdown of UPK1A-AS1 decreased the oxaliplatin resistance of tumor cells induced by IL8 as shown by cell viability assays (Fig. S4K, L), colony formation assays (Fig. S4M, N) and Annexin-V/PI apoptosis assays (Fig. S4O, P). Here, CXCL8 is linked to neoplasm.