Recently, two preclinical studies demonstrated the mechanisms by which IL8 mediates platinum resistance by transactivating ATP-binding cassette transporters, i.e., ABCB1 in gastric cancer cells [29] and ABCB5 in tumor-initiating cells of malignant pleural mesothelioma [46]. This evidence concerns the gene ABCB1 and malignant pleural mesothelioma.