To explore the influence of UPK1A-AS1 on oxaliplatin resistance in tumor cells, UPK1A-AS1 was overexpressed by transfection of a pcDNA3.1-based vector and knocked down by 2 specific siRNAs in Panc-1 and MIAPaCa-2 cells (Fig. S4B, C). The gene discussed is UPK1A; the disease is neoplasm.