Eight top-ranked genes with DC ≥15 and BC ≥3000 were identified as hub genes (NCOR2, DC = 56, BC = 17,272; PLEC, DC = 43, BC = 9545; DMD, DC = 32, BC = 9809.5; NEDD4, DC = 29, BC = 14,454; PIK3C2G, DC = 28, BC = 6210; ESR2, DC = 26, BC = 8177; EXO1, DC = 17, BC = 3768; TTN, DC = 17, BC = 3311.5, Fig. 4). The gene discussed is PLEC; the disease is breast cancer.