In summary, we highlighted two novel ethnicity-specific rare variants (rs146006146, c.815 G > A, p.R272H in OR51G1; rs763812068, c.142 C > T, p.Q48X in MLKL) and four hub genes (NCOR2, DMD, NEDD4, and PLEC) associated with AD pathogenesis. Here, MLKL is linked to Alzheimer disease.