APOE and Alzheimer disease: Also, when we examined association signals in all coding variants, one common variant in APOE, which has been reported as an AD susceptibility locus in several populations [7, 11], reached the GWAS significance level (rs429358, odds ratio [OR] = 4.23, 95% confidence interval [CI] 2.90–6.15, Pdiscovery < 5.0 × 10−8, Fig. S1).