Four of them have not been verified as expressed in brain tissues through the Human Protein Atlas database [31], which provides quantitative transcriptomics at the tissue and organ level and is publicly accessible at http://www.proteinatlas.org (Fig. S3), but we considered the remaining four (i.e., NCOR2, DMD, NEDD4, and PLEC) to be strong candidate hub genes associated with AD pathogenesis. This evidence concerns the gene PLEC and Alzheimer disease.