Four of them have not been verified as expressed in brain tissues through the Human Protein Atlas database [31], which provides quantitative transcriptomics at the tissue and organ level and is publicly accessible at http://www.proteinatlas.org (Fig. S3), but we considered the remaining four (i.e., NCOR2, DMD, NEDD4, and PLEC) to be strong candidate hub genes associated with AD pathogenesis. The gene discussed is NEDD4; the disease is Alzheimer disease.