HMGCR and Wilson disease: Our results showed that clitorin administration significantly decreased the mRNA levels of LXR, ACC, FAS, and HMGCR, which are lipogenic genes, and it also enhanced the mRNA levels of PPARα and CTP-1, fatty acid oxidation genes, as well as AMPK mRNA levels in the livers of WD-induced hepatic steatosis mice (Fig. 4E).