The international meta-GWAS comparing COVID-19 patients with the general population showed significant associations for nine genes: LZTFL1, CCHCR1, FOXP4-AS1, TMEMS, ABO, OAS family, KANSL1, DPP9, and IFNAR2. Seven genes, LZTFL1, CCHCR1, VSTM2A, OAS family, TAC4, DPP9, and IFNAR2, were significantly associated with severe COVID-19 patients compared with the general population. The gene discussed is TAC4; the disease is COVID-19.