SLC39A8 and rheumatoid arthritis: Regarding the expression of the importer ZIP-8, Cd had no effect in PVNS synoviocytes (Cd 0.1 ppm: 0.9 ± 0.1 fold; Cd 1 ppm: 1.1 ± 0.2 fold, Fig. 7) while Cd decreased ZIP-8 expression in RA synoviocytes compared to the control (Cd 0.1 ppm: 0.6 ± 0.2 fold; Cd 1 ppm: 0.6 ± 0.4 fold, Fig. 7).