In the presence of cytokines, Cd, at 0.1 or 1 ppm, decreased slightly ZIP-8 expression in both PVNS and RA synoviocytes compared to cytokines alone (PVNS: 3.9 ± 3.0 and 3.1 ± 1.8 fold, respectively, vs. 4.7 ± 3.0 fold, RA: 3.0 ± 2.1 and 2.8 ± 3.0 fold, respectively, vs. 4.9 ± 3.6, Fig. 7). This evidence concerns the gene SLC39A8 and rheumatoid arthritis.