The c.176_177delAG in BARD1, was quite common (0.24%) in the present series and, interestingly, it was also detected in other BC Brazilian patients, as well as in Spanish patients, but was not reported in a recent literature review of studies analyzing BARD1 as a cancer predisposing gene, mainly comprehending French or white people46,54,55. Here, BARD1 is linked to breast cancer.