SIRT2 and colorectal cancer: In addition, Gene Ontology, KEGG, and MetaCore pathway analyses identified that SIRT2 substrates are involved in diverse pathways, such as carbon metabolism, glycolysis, the spliceosome, RNA transport, RNA binding, transcription, the DNA damage response, the cell cycle, and colorectal cancer, expanding on the cellular pathways targeted by SIRT2, thus providing support for SIRT2 in regulating networks of proteins in diverse pathways and opening new avenues of investigation into SIRT2 function.