Consistent with Sirt2’s in vivo role in multiple physiological conditions and disease states, SIRT2 has been reported to deacetylate a number of substrates involved in diverse biological processes, including genome maintenance, aging, myelination, mitosis, cellular differentiation, oxidative stress, cellular homeostasis, infection, inflammation, and autophagy8,24–29. This evidence concerns the gene SIRT2 and infection.